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MDC1
Anti-MDC1 Recombinant Antibody Products
- Mouse Anti-MDC1 Recombinant Antibody (clone CBS390) (MRO-A1930-YJ)
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- Species Reactivity: Human, Mouse, Bovine, Chimpanzee
- Type: Mouse IgG
- Application: WB, ICC
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- Mouse Anti-NHP MDC1 Recombinant Antibody (clone P2B11) (VS-1024-XY320)
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- Species Reactivity: Bovine, Human, Mouse, Non-human primate
- Type: Mouse IgG1
- Application: WB, IF
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- Anti-MDC1 Immunohistochemistry Kit (VS-0325-XY1326)
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- Species Reactivity: Human
- Target: MDC1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Spermatocytes)
Immune cell specificity
Immune cell enriched (NK-cell)
Cell line specificity
Low cell line specificity
Interaction
Homodimer. Interacts with several proteins involved in the DNA damage response, although not all these interactions may be direct. Interacts with H2AX, which requires phosphorylation of H2AX on 'Ser-139'. Interacts with the MRN complex, composed of MRE11, RAD50, and NBN. Interacts with CHEK2, which requires ATM-mediated phosphorylation of 'Thr-68' within the FHA domain of CHEK2. Interacts constitutively with the BRCA1-BARD1 complex, SMC1A and TP53BP1. Interacts with ATM and FANCD2, and these interactions are reduced upon DNA damage. Also interacts with the PRKDC complex, composed of XRCC6/KU70, XRCC5/KU80 and PRKDC/XRCC7. This interaction may be required for PRKDC autophosphorylation, which is essential for DNA double strand break (DSB) repair. When phosphorylated by ATM, interacts with RNF8 (via FHA domain). Interacts with CEP164. When phosphorylated, interacts with APTX (via FHA-like domain).
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