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MDFI
Anti-MDFI Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts, Pancreatic endocrine cells, Extravillous trophoblasts, Urothelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BEWO, HBEC3-KT, OE19, REH)
Interaction
The C-terminus interacts with AXIN1 and LEF1 (By similarity). Interacts with CCNT2 (PubMed:17289077).
Molecular function
Developmental protein
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