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For Research Use Only. Not For Clinical Use.
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Cardiomyocytes)
Immune cell specificity
Immune cell enhanced (myeloid DC)
Cell line specificity
Cell line enhanced (CAPAN-2, hTERT-RPE1, HUVEC TERT2, TIME)
Molecular function
Oxidoreductase
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