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MGEA5

Anti-MGEA5 Products

Recombinant Rabbit Anti-MGEA5 Monoclonal Antibody (JG40-05) (MRO-0992-CN)
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC, IP
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Hi-Affi™ Recombinant Rabbit Anti-MGEA5 Monoclonal Antibody (DS2226AB) (MOR-2226)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, IP
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For Research Use Only. Not For Clinical Use.

The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (dendritic cells, Collecting duct cells, Glandular and luminal cells, Pancreatic endocrine cells, Granulosa cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Monomer (PubMed:11788610). Interacts with CLOCK (By similarity). (Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein Tax; this interaction increases Tax interacting partner CREB1 O-GlcNAcylation.

Molecular function

Glycosidase, Hydrolase

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