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MT-CO2
Anti-MT-CO2 Recombinant Antibody Products
- PE-B*57:01/Human MT-CO2 (LTTKLTNTNI) MHC Tetramer (MHC-LC1706)
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- Class: Class I
- Antigen: MT-CO2
- Antigen Species: Human
- Peptide: LTTKLTNTNI
- Conjugate: PE
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- APC-B*57:01/Human MT-CO2 (LTTKLTNTNI) MHC Tetramer (MHC-LC1707)
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- Class: Class I
- Antigen: MT-CO2
- Antigen Species: Human
- Peptide: LTTKLTNTNI
- Conjugate: APC
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- BV421-B*57:01/Human MT-CO2 (LTTKLTNTNI) MHC Tetramer (MHC-LC1708)
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- Class: Class I
- Antigen: MT-CO2
- Antigen Species: Human
- Peptide: LTTKLTNTNI
- Conjugate: BV421
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- PE-A*01:01/Human MT-CO2 (YTDYGGLIFNSY) MHC Tetramer (MHC-LC2376)
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- Class: Class I
- Antigen: MT-CO2
- Antigen Species: Human
- Peptide: YTDYGGLIFNSY
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.
MT-CO2 (Mitochondrially Encoded Cytochrome C Oxidase II) is a Protein Coding gene. Diseases associated with MT-CO2 include Mitochondrial Complex Iv Deficiency and Familial Colorectal Cancer. Among its related pathways are Development EGFR signaling via small GTPases and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and cytochrome-c oxidase activity.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Cardiomyocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HeLa)
Interaction
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded in the nuclear genome (PubMed:30030519). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2 (PubMed:29154948). Interacts with TMEM177 in a COX20-dependent manner (PubMed:29154948). Interacts with COX20 (PubMed:23125284, PubMed:24403053, PubMed:28330871, PubMed:29154948). Interacts with COX16 (PubMed:29355485, PubMed:29381136).
Molecular function
Translocase
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