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    For Research Use Only. Not For Clinical Use.


    Creative Biolabs is here to support your mitochondrial research and metabolic disease applications with our highly-selective anti-MT-CO2 recombinant antibodies. Mitochondrially encoded cytochrome c oxidase II (MT-CO2), also known as COX2, is one of three core, maternally-inherited subunits of Complex IV (Cytochrome c Oxidase), which plays a key role in cellular respiration. Our high quality antibodies can be used to study mitochondrial DNA mutations, Complex IV assembly defects, and mitochondrial disease pathology.

    MT-CO2: A Core Subunit of Complex IV Encoded by mtDNA

    Mitochondrially Encoded Cytochrome C Oxidase II (MT-CO2; COX2) is one of three core subunits of Complex IV (Cytochrome c Oxidase) that is maternally-inherited, and encoded by the mitochondrial DNA (mtDNA). As such, its translation is localized to the mitochondrial matrix and is dependent on mitochondrial transcription and translation machinery. Complex IV catalyzes the transfer of electrons to oxygen and pumps protons, and MT-CO2 is a component of the binding site for cytochrome c. Mutations in the MT-CO2 gene can cause a number of different severe mitochondrial disorders with defects in the organs with the highest energy demand such as the brain, heart, and muscle.

    Alternative Names

    Mitochondrially Encoded Cytochrome C Oxidase II; MTCO2; COII; Cytochrome C Oxidase Polypeptide II; Cytochrome C Oxidase Subunit II; Cytochrome C Oxidase II; EC 1.9.3.1; COXII; COX2

    Background

    MT-CO2 (Mitochondrially Encoded Cytochrome C Oxidase II) is a Protein Coding gene. Diseases associated with MT-CO2 include Mitochondrial Complex Iv Deficiency and Familial Colorectal Cancer. Among its related pathways are Development EGFR signaling via small GTPases and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and cytochrome-c oxidase activity.

    Protein class

    Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enriched (Cardiomyocytes)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (HeLa)

    Interaction

    Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded in the nuclear genome (PubMed:30030519). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2 (PubMed:29154948). Interacts with TMEM177 in a COX20-dependent manner (PubMed:29154948). Interacts with COX20 (PubMed:23125284, PubMed:24403053, PubMed:28330871, PubMed:29154948). Interacts with COX16 (PubMed:29355485, PubMed:29381136).

    Molecular function

    Translocase

    More Types Infomation

    Anti-MT-CO2 rAb Products

    Creative Biolabs' anti-MT-CO2 recombinant antibodies (rAbs) have been optimized for high specificity and performance. They are extensively validated for accurate detection of the MT-CO2 protein in mitochondrial subcellular fractions. They can be used in Western Blot to monitor the integrity of Complex IV assembly, or for IHC, and are guaranteed to be specific and consistent tools for your metabolic research.

    Table 1. Featured anti-MT-CO2 recombinant antibody products at Creative Biolabs.

    Cat. No. Product Name Target Species Host Species Applications
    VS3-FY967 Recombinant Rabbit Anti-MT-CO2 Antibody (clone R05-2E2) Human Rabbit IgG WB, IHC-Fr, IHC-P, ICC, IF, IP
    MOB-0132CT Recombinant Mouse anti-Human MT-CO2 Monoclonal antibody (23D5G23) Human Mouse IgG FC, ICC, IF, WB

    Creative Quality Control

    Creative Biolabs is dedicated to the highest level of scientific rigor. The production process for our anti-MT-CO2 recombinant antibodies is tightly controlled by a comprehensive quality assurance process. We test each lot of product extensively for purity, specificity, and consistent performance in validated mitochondrial applications so that you can rely on receiving a high quality reagent.

    Fig.1 WB analysis. (Creative Biolabs Original) Fig.1 WB analysis of anti-MT-CO2 antibody
    (Cat# VS3-FY967, Creative Biolabs).

    Fig.2 ICC analysis. (Creative Biolabs Original) Fig.2 ICC analysis of anti-MT-CO2 antibody
    (Cat# VS3-FY967, Creative Biolabs).

    Customer Reviews

    Excellent
    Ali**x
    Recombinant Rabbit Anti-MT-CO2 Antibody (clone R05-2E2)
    The anti-MT-CO2 antibody from Creative Biolabs was critical for our study. We were able to confirm on Western blot of mitochondrial fractions that its expression is downregulated in our disease model.
    11/Sep/2023

    rAb Production

    At Creative Biolabs, we have invested in advanced recombinant antibody production platforms to support your needs for mitochondrial research. Our anti-MT-CO2 recombinant antibodies are expressed in a highly optimized system to ensure accurate recognition of the native protein and a highly specific, active antibody.

    Featured Anti-MT-CO2 Recombinant Antibody Production PlatformsFig.3 Milligram-scale. (Creative Biolabs Original)
    Fig.3 Milligram-scale anti-MT-CO2 recombinant antibody production.

    Fig.4 Gram-scale. (Creative Biolabs Original)Fig.4 Gram-scale anti-MT-CO2 recombinant antibody production.

    rAb Modalities

    Creative Biolabs is committed to advancing science by providing flexible and customizable antibody products. Our anti-MT-CO2 recombinant antibodies are available in a variety of modalities so you can find the right antibody for your research needs.

    Fig.5 MT-CO2 antibody production and modalities. (Creative Biolabs Original)Fig.5 Full-length anti-MT-CO2 recombinant antibody production and modalities.

    Get accurate, consistent results for your research in mitochondrial genetics and metabolism with Creative Biolabs' high quality anti-MT-CO2 recombinant antibodies. Our portfolio of rigorously validated and consistent reagents is ready to support your study of this important Complex IV subunit. Trust Creative Biolabs with your research needs. Contact our experts today.

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