Anti-MTHFD2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a leader in the research and development of cancer metabolism, and our anti-MTHFD2 recombinant antibodies are no exception. The MTHFD2 protein is a mitochondrial enzyme involved in the one-carbon metabolic network that is widely overexpressed in cancer cells while silenced in most normal adult tissues. Our top tier anti-MTHFD2 antibodies provide the tools needed to further understand cancer metabolism and its related pathways, develop new chemotherapies, and identify new metabolic targets for cancer therapeutics.

MTHFD2: A Mitochondrial Engine for Cancer Cell Proliferation

Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) is a mitochondrial enzyme involved in one-carbon metabolism that catalyzes two consecutive reactions of the folate cycle. MTHFD2 is a housekeeping gene that is highly expressed during embryogenesis but is silenced in most adult differentiated tissues. By contrast, MTHFD2 is hyper-expressed in a broad range of cancers, where it fuels the biosynthesis of nucleotides and other macromolecules required for the proliferation of cancer cells. The highly cancer-specific expression profile of MTHFD2 makes it an ideal and highly druggable target for next-generation cancer therapeutics.

Alternative Names

NMDMC

Background

The protein encoded by this gene is a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. This enzyme is a homodimer. It is distinct in having an absolute requirement for magnesium and inorganic phosphate. Binding of magnesium is necessary for the enzyme-NAD complex to form. Two different transcripts have been described as a result of alternative splicing, one protein-coding and one not protein-coding. There is a pseudogene of this gene on chromosome 7.

Anti-MTHFD2 rAb Products

Our recombinant antibodies to MTHFD2 are engineered to deliver reliable specificity and sensitivity so you can trust their detection of this important mitochondrial enzyme. We validate every batch to demanding applications, like IHC to evaluate expression in tumors and Western Blotting of mitochondrial fractions, to ensure our recombinant antibodies provide the level of precision you need for high-impact oncology research.

Table 1. Featured anti-MTHFD2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs' commitment to helping researchers make the next big discoveries in oncology includes investment in leading edge production platforms. We express our anti-MTHFD2 recombinant antibodies in optimized systems that ensure high fidelity in recognition of the native enzyme, so you can trust that the product we deliver has the highest possible biological relevance and activity for your research.

Featured Anti-MTHFD2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-MTHFD2 recombinant antibody production.

Fig.2 Gram-scale anti-MTHFD2 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to flexible and innovative solutions to meet the needs of today's cancer researchers. Our anti-MTHFD2 recombinant antibodies are available in a range of customizable modalities, so researchers worldwide can study this important cancer-specific metabolic enzyme.

Fig.3 Full-length anti-MTHFD2 recombinant antibody production and modalities.

Study the roles of MTHFD2 in cancer with the precision of Creative Biolabs recombinant antibodies. Defined by stringent validation and exceptional consistency, our rAbs provide the ideal tools to learn more about this important oncogenic protein. Work with us for the quality to win. Contact our experts today.