MYC Phosphorylation

MYC is a potent and pleiotropic transcription factor that sits at a critical nexus of cellular control. It regulates the expression of a vast number of genes, influencing nearly every aspect of cell biology, including cell growth, proliferation, metabolism, differentiation, and apoptosis. Given its fundamental role, MYC protein levels and activity are exquisitely regulated, and even subtle dysregulation can have profound consequences, often leading to uncontrolled cell division and contributing to the development and progression of various cancers. One of the most important regulatory mechanisms for MYC's stability and function is its phosphorylation.