Disease related genes, Human disease related genes, Plasma proteins
Intracellular
Cell type enhanced (Oligodendrocytes)
Group enriched (gdT-cell, memory CD8 T-cell, naive CD8 T-cell, MAIT T-cell, NK-cell, memory CD4 T-cell)
Cell line enhanced (RT4)
Homodimer; dimerization seems to implicate the unfolding of the three-helix bundle region creating an additional calmodulin binding site, and cargo binding (By similarity). Able to function as a monomer under specific conditions in vitro (PubMed:15044955). Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells (PubMed:15247260). Component of the DISP/DOCK7-induced septin displacement complex, at least composed of DOCK7, LRCH3 and MYO6 (PubMed:29467281). Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal (By similarity). This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium (By similarity). Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (By similarity). Interacts with DAB2 (PubMed:11967127). In vitro, the C-terminal globular tail binds a C-terminal region of DAB2 (By similarity). Interacts with CFTR (PubMed:15247260). Interacts with OPTN (By similarity). Interacts with CABP5 (By similarity).
Actin-binding, Calmodulin-binding, Motor protein, Myosin
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For Research Use Only. Not For Clinical Use.