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NAIP

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Protein class

Cancer-related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Kupffer cells, Microglial cells, Macrophages)

Immune cell specificity

Immune cell enhanced (classical monocyte, myeloid DC)

Cell line specificity

Cell line enhanced (MOLT-4, SiHa, T-47d)

Interaction

Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains). Interacts with C.violaceum needle protein CprI.

Molecular function

Protease inhibitor, Thiol protease inhibitor

More Types Infomation

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