Anti-NAIP Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is at the forefront of innate immunity and inflammation research, and we offer premium anti-NAIP recombinant antibodies. NAIP is a critical intracellular sensor for bacterial proteins, and an important initiator of the inflammasome pathway. Our high-quality anti-NAIP antibodies are important reagents in research of host-pathogen interactions, inflammatory diseases, and pyroptotic cell death mechanisms.

NAIP: The Intracellular Sensor for Bacterial Flagellin and T3SS Proteins

NLR Family Apoptosis Inhibitory Protein (NAIP) belongs to a family of intracellular pattern recognition receptors known as Nod-like Receptor (NLR). NAIP acts as a direct cytosolic sensor for defined bacterial components. Human NAIP, for instance, senses the rod protein of bacterial Type III secretion systems (T3SS) directly, while mouse Naip5 directly detects flagellin. NAIP undergoes a conformational change and co-oligomerizes with NLRC4 when bound to its cognate ligand, and forms the core of NLRC4 inflammasome. The NLRC4 inflammasome complex then proceeds to recruit and activate caspase-1. The activity of caspase-1 is crucial for the proteolytic cleavage of pro-inflammatory cytokines (IL-1β, IL-18) and gasdermin D, which causes a fiery, pro-inflammatory mode of programmed cell death called pyroptosis.

Alternative Names

BIRC1; NLRB1; psiNAIP

Background

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions.

Anti-NAIP rAb Products

Our anti-NAIP recombinant antibodies are engineered to be highly specific and perform well in detecting this important intracellular sensor. The antibodies are carefully validated for their use in Western Blot to measure expression levels as well as co-immunoprecipitation applications to study the assembly of the NLRC4 inflammasome complex. Expect nothing but consistency with our rAbs.

Table 1. Featured anti-NAIP recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

At Creative Biolabs, we understand the intricacies of innate immunity research, and have tailored our antibody production platforms to meet the high standards of this specialized field. We use the latest production technologies to express our anti-NAIP recombinant antibodies in highly optimized systems that ensure that they recognize the native protein of interest, delivering a highly specific and active antibody for your research.

Featured Anti-NAIP Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-NAIP recombinant antibody production.

Fig.2 Gram-scale anti-NAIP recombinant antibody production.

rAb Modalities

Creative Biolabs empowers scientific discovery by providing flexible antibody modalities. We have carefully designed our anti-NAIP recombinant antibodies to be offered in a range of formats so that they can be customized to meet your experimental needs. No matter where you are in the world, our diverse antibody solutions help you explore this key sensor of bacterial infection.

Fig.3 Full-length anti-NAIP recombinant antibody production and modalities.

Explore the critical functions of NAIP/NLRC4 inflammasome with Creative Biolabs' recombinant antibodies. Our portfolio is known for its high specificity and thorough validation to ensure that our antibodies will serve as the perfect reagents for your research into infectious and inflammatory diseases. Choose quality that speeds discovery. Contact our experts today.