Anti-NARS Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your trusted development partner for basic cell biology and rare disease research. We provide highly specific anti-NARS1 recombinant antibodies. Cytoplasmic Asparaginyl-tRNA Synthetase 1 (NARS1) is the enzyme that charges tRNAs with the amino acid asparagine. It is a housekeeping protein that is indispensable for protein synthesis. Our high-quality antibodies help you to dissect the mechanisms of translation and to understand rare neurodevelopmental diseases caused by mutations in NARS1.

NARS: The Cytoplasmic Gatekeeper of Asparagine in Protein Synthesis

Asparaginyl-tRNA Synthetase 1 (NARS1) is a housekeeping enzyme localized to the cytoplasm. It is a member of the aminoacyl-tRNA synthetases family. Aminoacyl-tRNA synthetases are responsible for the first step of protein synthesis. NARS1 recognizes and catalyzes the ligation of asparagine and its cognate transfer RNA (tRNA-Asn) in an ATP-dependent manner. This reaction "charges" tRNA-Asn with asparagine, which is a prerequisite for the amino acid's incorporation into growing polypeptide chains in the process of translation. Bi-allelic mutations in the NARS1 gene abrogate this crucial function, causing rare neurodevelopmental diseases.

Alternative Names

NARS; Asparagine--TRNA Ligase, Cytoplasmic; AsnRS; Asparagine TRNA Ligase 1; Asparaginyl-TRNA Synthetase, Cytoplasmic; Cytoplasmic; EC 6.1.1.22

Background

Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

Anti-NARS rAb Products

Creative Biolabs' anti-NARS1 recombinant antibodies are designed with the utmost specificity and performance in mind. We have rigorously validated our reagents to ensure that they specifically detect the cytoplasmic NARS1 enzyme and not its mitochondrial homolog NARS2. This isoform specificity is of the utmost importance in research. Our rAbs are optimized for Western Blot and immunoprecipitation, providing you with clean and consistent data in your molecular biology applications.

Table 1. Featured anti-NARS recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is committed to supporting scientific rigor and accuracy in research. Creative Biolabs' anti-NARS1 recombinant antibodies are produced under a strict quality control regimen. Each production lot is extensively validated for purity, isoform specificity, and performance in our validated applications, and only reagents that meet our highest standards are shipped to our customers.

Fig.1 ELISA analysis of anti-NARS antibody (Cat# ZG-448C, Creative Biolabs).

Customer Reviews

rAb Production

Creative Biolabs is committed to facilitating cutting-edge research on the most fundamental mechanisms in molecular biology. We have established high-quality production platforms to provide you with the best antibodies. Our anti-NARS1 recombinant antibodies are produced in highly optimized systems that result in a reagent that will accurately recognize the native enzyme in your samples, providing you with a specific and active tool for your most challenging experiments.

Featured Anti-NARS Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-NARS recombinant antibody production.

Fig.3 Gram-scale anti-NARS recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to advancing science by providing high-quality antibody solutions for your needs. Our anti-NARS1 recombinant antibodies are available in a variety of formats that can be customized to your exact specifications. Explore the fundamental mechanisms of protein synthesis and their implications for human disease with Creative Biolabs' broad selection of cutting-edge antibody reagents.

Fig.4 Full-length anti-NARS recombinant antibody production and modalities.

Explore the intricacies of protein translation with Creative Biolabs' high-quality anti-NARS1 recombinant antibodies. We have isoform-specific antibodies that have been rigorously validated for accuracy, providing you with the tools you need to study this essential enzyme. Trust Creative Biolabs for a solid foundation in your molecular biology research. Speak to a member of our scientific team today.