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NASP
Anti-NASP Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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- AbPlus™ Anti-NASP Magnetic Beads (VS-0724-YC1094) (VS-0724-YC1094)
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- Target: NASP
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-NASP Immunohistochemistry Kit (VS-0325-XY1453)
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- Species Reactivity: Human, Mouse, Rat
- Target: NASP
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatogonia, Spermatocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Binds to linker H1 histones but not to core histones (By similarity). Interacts with histones H2A, H2B, H3 and H4 (PubMed:8724350, PubMed:27618665). Interacts with histone H3.3 (PubMed:33857403). Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to H1-6/H1T (By similarity).
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