Anti-NAT1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a trusted source of reagents for pharmacogenomics and cancer research, including our high-quality anti-NAT1 recombinant antibodies. N-acetyltransferase 1 (NAT1) is a phase II drug-metabolizing enzyme, and variants of the NAT1 gene affect individual response to a wide variety of therapeutic drugs as well as carcinogens. Creative Biolabs' validated anti-NAT1 antibodies are a key tool for drug metabolism, toxicology, and cancer susceptibility studies.

NAT1: A Key Player in Drug Metabolism and Carcinogenesis

N-acetyltransferase 1 (NAT1) is a cytosolic enzyme that acetylates arylamine and heterocyclic amine substrates. NAT1 is involved in metabolism of many therapeutic drugs and is also responsible for detoxification of environmental carcinogens. In some cases, NAT1 bioactivates pro-carcinogens, which makes it a risk factor for carcinogenesis in various tissues such as the bladder and colon. Polymorphisms of the NAT1 gene give rise to fast, slow, and intermediate acetylator phenotypes which significantly affect therapeutic efficacy and susceptibility to toxicity in affected individuals. NAT1 is therefore an important pharmacogenomic biomarker and an active area of personalized medicine.

Alternative Names

N-Acetyltransferase 1; N-Acetyltransferase 1 (Arylamine N-Acetyltransferase); Monomorphic Arylamine N-Acetyltransferase; Arylamine N-Acetyltransferase 1; N-Acetyltransferase Type 1; Arylamide Acetylase 1

Background

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.

Anti-NAT1 rAb Products

Creative Biolabs' anti-NAT1 recombinant antibodies are designed and validated for the highest possible specificity and performance. Our antibodies are rigorously tested and curated to eliminate cross-reactivity with its homolog NAT2 for accurate measurement of acetylator status and enzyme expression. Optimized for Western Blot and IHC, our rAbs are designed to give reliable and unequivocal data for your high-impact research.

Table 1. Featured anti-NAT1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has the production platforms necessary to meet the unique needs of toxicology and personalized medicine researchers. Our anti-NAT1 recombinant antibodies are produced in optimized systems to ensure correct folding and native conformation of the recombinant protein so the antibodies recognize the native enzyme and provide you with a specific and active reagent for your most sensitive applications.

Featured Anti-NAT1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-NAT1 recombinant antibody production.

Fig.2 Gram-scale anti-NAT1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to driving scientific discovery with flexible and innovative antibody solutions. Our anti-NAT1 recombinant antibodies are available in multiple customizable formats to meet the needs of a variety of experimental designs, providing researchers around the globe with the tools they need to study this important drug-metabolizing enzyme and its role in human health.

Fig.3 Full-length anti-NAT1 recombinant antibody production and modalities.

Learn more about the role of NAT1 in drug metabolism and disease using Creative Biolabs' high-specificity recombinant antibodies. Our portfolio of research tools have the specificity and reliability you need to study this key pharmacogenomic biomarker. You can depend on our quality to give your work a solid foundation. Contact our expert team today to see what we can do for your research.