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NELL2
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis.
Protein class
Plasma proteins
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Excitatory neurons)
Immune cell specificity
Immune cell enhanced (naive CD8 T-cell, naive CD4 T-cell)
Cell line specificity
Cell line enhanced (AF22, HEK93, NTERA-2, SCLC-21H, U-266/70, U-266/84, U-698)
Interaction
Homotrimer. Binds to PKC beta-1 (By similarity).
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