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NFIC

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Protein class

Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Hepatocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (SiHa, U-2197)

Interaction

Binds DNA as a homodimer.

Molecular function

Activator, DNA-binding

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