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NKAP
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- Chicken Anti-NKAP Polyclonal IgY (BRD-0393MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the Notch corepressor complex. Interacts with CIR1 and HDAC3.
Molecular function
Repressor
More Types Infomation