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NKp46
Loading...Anti-NKp46 Products
- Mouse Anti-NKp46 Recombinant Antibody (HPAB-N0192-YC) (HPAB-N0192-YC)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, ELISA
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- Mouse Anti-NKp46 Recombinant Antibody; scFv Fragment (HPAB-N0192-YC-S(P)) (HPAB-N0192-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, ELISA
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- Mouse Anti-NKp46 Recombinant Antibody; Fab Fragment (HPAB-N0192-YC-F(E)) (HPAB-N0192-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, ELISA
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For Research Use Only. Not For Clinical Use.
Background
Three activating receptors found on NK cells, NKp30, NKp44, and NKp46, are collectively known as Natural Cytotoxicity Receptors (NCRs). These receptors are crucial in NK cells antitumor and antiviral defenses. NKp46 has been established as a critical activating receptor since it is expressed almost exclusively by NK cells and is the only NCR with a mouse orthologue. Its ligand repertoire ranges from viral ligands, such as, hemagglutinin (HA) and hemagglutinin-neruamindase (HN) of influenza virus, Sendai virus, Newcastle disease virus, and poxvirus, to unknown ligands found on bacteria, such as Fusobacterium nucleatum, tumors, adipose cells, and human pancreatic beta cells.