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NLRC3
This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells, T-cells, dendritic cells, B-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, HEL, HL-60, HMC-1, JURKAT, NB-4, U-698, U-937)
Interaction
Directly interacts (via CARD) with TMEM173/STING; this interaction reduces TMEM173 trafficking to the perinuclear region in response to interferon stimulatory DNA. Also interacts, but to a lesser extent, with TBK1 (PubMed:24560620). Interacts with TRAF6; this interaction results in decreased TRAF6 'Lys-63'-linked polyubiquitination, but leaves 'Lys-48'-linked chains unchanged, promoting TRAF6 protein degradation (PubMed:22863753). Interacts with PIK3R1/PIK3R2; this interaction disrupts the association between PIK3R1/PIK3R2 and the p110 catalytic subunit PIK3CA/PIK3CB/PIK3CD and reduces PIK3R1/PIK3R2 activation (By similarity). Weakly interacts with PYCARD/ASC. Interacts with CASP1 and CASP5 (PubMed:25277106).
More Types Infomation
- Rabbit Anti-NLRC3 Polyclonal Antibody (MRO-2075-CN) (MRO-2075-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IF, IHC, FC
- Rabbit Anti-NLRC3 Polyclonal Antibody (MRO-2074-CN) (MRO-2074-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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