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NPY1R
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For Research Use Only. Not For Clinical Use.
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity.
Protein class
G-protein coupled receptors
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Hepatic stellate cells, Sertoli cells, Excitatory neurons, Smooth muscle cells, Enteroendocrine cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (HEL)
Molecular function
G-protein coupled receptor, Receptor, Transducer
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