Anti-NR1H4 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a trusted provider of innovative research reagents for hepatology and metabolic disease, and we are proud to offer some of the best anti-NR1H4 (FXR) recombinant antibodies available. FXR, the master nuclear receptor that controls bile acid, lipid, and glucose homeostasis, is an attractive therapeutic target for liver diseases such as NASH. Our high-quality antibodies will be invaluable tools for researchers studying the regulation of liver metabolism and for the discovery of novel FXR agonists.

NR1H4: The Master Regulator of Bile Acid Metabolism

Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4), also known by the universal name Farnesoid X Receptor (FXR), is a nuclear receptor that acts as the body's sentinel for bile acids. Bile acid-FXR complex dimerizes with RXR in the liver and intestine and binds to DNA to transcriptionally control an extensive network of genes that govern every aspect of bile acid synthesis, transport, and detoxification. In addition to controlling bile acid homeostasis, FXR activation reduces triglycerides, enhances insulin sensitivity, and exerts anti-inflammatory and anti-fibrotic effects in the liver. Because of this, it has become a prime therapeutic target for cholestatic liver diseases and non-alcoholic steatohepatitis (NASH).

Alternative Names

NR1H4; Human NR1H4

Background

This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described.

Anti-NR1H4 rAb Products

Creative Biolabs' anti-NR1H4 recombinant antibodies are engineered for superior specificity and performance. They are validated to detect the FXR protein in nuclear extracts and tissue lysates. Optimized for challenging applications like Western Blot, IHC, and Chromatin Immunoprecipitation (ChIP), our rAbs provide the specificity you need to study the complex transcriptional regulation controlled by this important nuclear receptor.

Table 1. Featured anti-NR1H4 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

To help speed the discovery of novel metabolic therapeutics, Creative Biolabs has invested in leading-edge antibody production platforms. Our anti-NR1H4 recombinant antibodies are expressed in optimized systems designed to ensure they faithfully recognize the native receptor so you can trust you will receive a product with high biological activity for your research.

Featured Anti-NR1H4 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-NR1H4 recombinant antibody production.

Fig.2 Gram-scale anti-NR1H4 recombinant antibody production.

rAb Modalities

Creative Biolabs is focused on providing innovative products for endocrinology research. Our anti-NR1H4 recombinant antibodies are available in a range of customizable modalities to empower researchers around the world to study this key metabolic regulator.

Fig.3 Full-length anti-NR1H4 recombinant antibody production and modalities.

Target the master regulator of liver metabolism with Creative Biolabs' premium anti-NR1H4 recombinant antibodies. We have the specificity and functional activity you need to study this important therapeutic target, and our team has the expertise and dedication you can trust to provide a strong foundation for the next generation of liver disease therapeutics. Contact our scientific team today.