Anti-NT5M Recombinant Antibody Products

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Anti-NT5M Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in high-performance recombinant antibodies against NT5M, empowering researchers to push boundaries in biomedical science. Our advanced development platforms guarantee rigorously validated products with consistent reliability. Beyond supplying premium reagents, we provide expert technical guidance to support your experimental workflow from design to data analysis. Partner with us to access tailored antibody solutions backed by scientific excellence and responsive customer service.

NT5M: A Pivotal Regulator in Metabolic Disorders Cancer Resistance and Neurological Diseases

NT5M, a key enzyme in nucleotide metabolism, plays a critical role in maintaining cellular homeostasis and has been implicated in various disease pathways. As a cytosolic 5'-nucleotidase, it regulates purine and pyrimidine levels by hydrolyzing nucleoside monophosphates, influencing DNA repair, replication, and energy metabolism. Dysregulation of this enzyme disrupts nucleotide balance, contributing to metabolic disorders such as mitochondrial dysfunction and impaired energy production. In cancer, aberrant activity is linked to chemoresistance, as altered nucleotide pools enable tumor cells to evade therapy-induced DNA damage. Evidence also suggests involvement in cardiovascular diseases, where disrupted purine metabolism exacerbates ischemic injury and oxidative stress. Neurological conditions, including neurodegenerative disorders, may arise from impaired nucleotide recycling, leading to synaptic dysfunction and neuronal death. Additionally, its role in immune modulation highlights potential connections to autoimmune and inflammatory diseases. Given its broad impact on cellular processes, targeting this pathway offers therapeutic potential for conditions characterized by metabolic imbalance, genomic instability, or aberrant proliferation. Research continues to explore its mechanisms in disease progression and treatment resistance.

Alternative Names

Complement NT5M; 5,3-nucleotidase, mitochondrial; mdN; dNT2; dNT-2; 5(3)-deoxyribonucleotidase, mitochondrial; deoxy-5-nucleotidase 2; 5(3)-deoxyribonucleotidase; mitochondrial 5 nucleotidase; 5 nucleotidase, mitochondrial

Background

This gene encodes a 5 nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5- and 2(3)-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17.

Anti-NT5M rAb Products

We accelerate scientific breakthroughs by providing premium anti-NT5M recombinant antibodies, combining rigorous quality standards with expert technical assistance to support your research goals.

Table 1. Featured anti-NT5M recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

So**e
Recombinant Mouse anti-Human NT5M Monoclonal antibody (EML1700) (CAT#: MOB-1470CT)

Recombinant Mouse anti-Human NT5M works well in WB for detecting endogenous protein in HEK293 and HepG2 lysates. Tested in human liver and kidney tissues, it shows clean bands with minimal background when using 3% BSA blocking. While it performs consistently in overexpression systems, detection in low-expression samples may require optimization. No cross-reactivity observed with related nucleotidases. A reliable option for basic research applications.

05/Mar/2024

Excellent

A**as
Recombinant Mouse anti-Human NT5M Monoclonal antibody (EML1700) (CAT#: MOB-1470CT)

The EML1700 anti-NT5M antibody has proven useful for comparative studies across different cell lines. In our hands, it consistently detected the target in both normal and cancer cell lysates with good specificity. The antibody worked particularly well for monitoring NT5M expression changes under metabolic stress conditions. While the signal intensity is moderate rather than exceptionally strong, we appreciated the clean background when using recommended protocols. Storage stability appears good after several freeze-thaw cycles.

11/Nov/2024

rAb Production

With extensive experience in recombinant antibody development, we deliver premium-quality products efficiently while maintaining rigorous quality standards.

Featured Anti-xx Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs provides researchers with a comprehensive portfolio of high-performance recombinant antibodies, available in multiple formats. Leveraging advanced engineering techniques, we deliver precisely tailored solutions supported by customized services to meet diverse research requirements.

Fig.3 Full Length Anti-NT5M Recombinant Antibody Production and Modalities.

For further details about NT5M, please contact our expert team by phone or email. We're always ready to provide technical guidance and troubleshooting assistance to help overcome experimental challenges and optimize your research outcomes. Our specialists are available to answer your specific questions and ensure you receive the necessary support throughout your project.