Intracellular
Cell type enhanced (Basal respiratory cells)
Immune cell enhanced (basophil)
Cell line enhanced (HHSteC, hTCEpi, SK-MEL-30, T-47d, U-87 MG)
Monomer. Directly interacts with MSL1 and binds MORF4L1, two components of histone acetyltransferase complex; the interaction with MORF4L1 may be mediated by MSL1 (PubMed:19650074). Interacts with EP300; this interaction enhances the effect of EP300 on PAX2 transcription factor activity (PubMed:11940591). Interacts with PAXIP1; this interaction prevents PAXIP1 inhibition of PAX2 transcription factor activity (PubMed:11940591). Interacts with COPS5; this interaction allows COPS5-dependent CDKN1B nuclear to cytoplasm translocation (PubMed:16300740). Interacts with RNF2 (PubMed:28720707). Interacts with FOXO3; this interaction represses FOXO3 transactivation (PubMed:20181828). Interacts with PTMA; negatively regulates apoptotic process (PubMed:16478804). Interacts with MYOD1, EP300 and DDX5; this interaction coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter (PubMed:19723804) (By similarity). Interacts with TP53; interaction is stress-dependent (PubMed:18690848). Forms a complex with EP300 and TP53; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848).
Activator, DNA-binding
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For Research Use Only. Not For Clinical Use.