Anti-OGDH Recombinant Antibody Products

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Anti-OGDH Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs takes pride in delivering premium recombinant antibodies targeting OGDH, strategically designed to support and elevate biomedical research through innovative solutions. By leveraging state-of-the-art technology platforms, we ensure our products adhere to the most rigorous quality and performance benchmarks, providing researchers with robust tools to advance their work. Our diverse portfolio of recombinant solutions is meticulously crafted to offer both unwavering reliability and tangible research value, catering to a wide spectrum of scientific needs. Beyond our top-tier antibodies, we provide expert technical guidance tailored to assist scientists at every stage of their experimental journey, fostering a collaborative environment focused on overcoming challenges. Partnering with Creative Biolabs means gaining access to forward-thinking research tools and a dedicated team committed to driving your research success, combining excellence in product innovation with proactive support at every step.

OGDH: A Central Metabolic Regulator in Neurodegeneration and Cancer

OGDH is a critical mitochondrial enzyme in the tricarboxylic acid (TCA) cycle whose dysfunction underlies multiple pathological conditions. As a rate-limiting component of the multi-enzyme complex converting α-ketoglutarate to succinyl-CoA, OGDH plays a pivotal role in energy metabolism, with its impairment directly linked to neurodegenerative diseases like Alzheimer's and Parkinson's through mechanisms involving oxidative stress, bioenergetic failure, and aberrant glutamate signaling. The enzyme's susceptibility to reactive oxygen species makes it particularly vulnerable in ischemic conditions, contributing to reperfusion injury in stroke and myocardial infarction. In cancer biology, OGDH exhibits dual roles—while its downregulation promotes the Warburg effect in many tumors, certain malignancies demonstrate OGDH overexpression to sustain anabolic pathways. Metabolic disorders including type 2 diabetes show altered OGDH activity affecting glucose homeostasis, while inborn errors of OGDH function cause severe developmental delays and lactic acidosis. Recent evidence implicates OGDH in immune regulation through its influence on citrate metabolism and inflammatory signaling, suggesting therapeutic potential in autoimmune diseases. The enzyme's structural complexity, with its thiamine pyrophosphate cofactor requirement and multiple regulatory sites, presents unique opportunities for pharmacological modulation across these diverse disease contexts, though targeting specificity remains challenging due to its central metabolic position.

Alternative Names

Complement OGDH; 2-Oxoglutarate Dehydrogenase, Mitochondrial; Oxoglutarate (Alpha-Ketoglutarate) Dehydrogenase (Lipoamide); 2-Oxoglutarate Dehydrogenase Complex Component E1; OGDC; OGDC-E1; Alpha-Ketoglutarate Dehydrogenase; Oxoglutarate Dehydrogenase (Succinyl-Tran

Background

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-OGDH rAb Products

Our mission is to drive scientific advancement by providing high-quality anti-OGDH recombinant antibodies that seamlessly integrate exceptional performance, cost-efficiency, and reliable technical support, all designed to empower researchers and streamline their journey toward breakthrough discoveries.

Table 1. Featured anti-OGDH recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

Mi**l
Mouse Anti-OGDH Recombinant Antibody (clone 30F5) (CAT#: MOB-2172z)

We used the Mouse Anti-OGDH Recombinant Antibody for ELISA assays on human liver tissue samples. The antibody showed good specificity and consistent performance across replicates. It worked well under our standard conditions without the need for extra optimization. Overall, it's a reliable tool for detecting OGDH in our experiments.

11/Mar/2024

Excellent

S**ia
Recombinant Mouse Anti-Human OGDH Antibody (clone 0G5CE6) (CAT#: MOB-2218MZ)

I tested the Recombinant Mouse Anti-Human OGDH Antibody in Western blot using lysates from HEK293 cells. The bands were clear and matched the expected molecular weight, with minimal background. It performed reliably across multiple runs and required no major protocol adjustments. A solid option for routine WB analysis.

10/Nov/2023

rAb Production

Drawing on our deep expertise in recombinant antibody development, we are focused on delivering high-quality products with efficiency and reliability at the core. Our dedicated service model ensures swift turnaround times and consistently superior performance, effectively supporting a broad spectrum of research requirements across diverse scientific disciplines.

Featured Anti-OGDH Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to offering researchers an extensive array of cutting-edge recombinant antibodies in various formats, reflecting our proficiency across diverse antibody engineering strategies that prioritize both versatility and performance. Beyond our core portfolio, we provide expert customization services meticulously tailored to address the unique and specific requirements of your research projects, ensuring solutions that align precisely with your scientific objectives and drive impactful results.

Fig.3 Full Length Anti-OGDH Recombinant Antibody Production and Modalities.

For comprehensive insights about the OGDH target or specialized technical support, our expert team welcomes your inquiry through phone or email communication. We stand prepared to offer customized solutions for any experimental challenges you may face, ensuring your research maintains optimal progress - please don't hesitate to get in touch with our specialists for dedicated assistance tailored to your scientific objectives.