Disease related genes, Human disease related genes
Intracellular
Cell type enhanced (Erythroid cells, Extravillous trophoblasts, Spermatogonia, Plasma cells, Early spermatids, Cytotrophoblasts)
Immune cell enhanced (NK-cell)
Low cell line specificity
Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.
DNA-binding
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For Research Use Only. Not For Clinical Use.