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ORF1ab

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For Research Use Only. Not For Clinical Use.


Background

orf1ab, or Orf1a polyprotein, is a large precursor protein encoded by coronaviruses (e.g., SARS-CoV-2). Orf1ab is proteolytically cleaved by viral proteases into multiple nonstructural proteins (nsps) that form the viral replication and transcription complex (RTC), essential for viral RNA synthesis and replication.
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