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OXCT1

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate
Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Cardiomyocytes, Distal tubular cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HeLa, SiHa)

Interaction

Homodimer (PubMed:10964512, PubMed:23420214). Only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) (By similarity).

Molecular function

Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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