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PASD1

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma.
Predicted location

Intracellular

Single cell type specificity

Group enriched (Spermatogonia, Spermatocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (BEWO, HMC-1, U-266/84)

Interaction

Interacts with the CLOCK-ARNTL/BMAL1 heterodimer; this interaction inhibits CLOCK-ARNTL/BMAL1 transcriptional activation and suppress circadian timekeeping (PubMed:25936801). Interacts with ARNTL/BMAL1 (PubMed:25936801).

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