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PCBP1

Anti-PCBP1 Products
- Rabbit Anti-PCBP1 Polyclonal Antibody (MRO-2110-CN) (MRO-2110-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
- Mouse Anti-PCBP1 Antibody, mRNA (TAB-702CL-mRNA)
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- Species Reactivity: Human
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- Derivation: Mouse
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Antibody
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IP
- Anti-PCBP1 Immunohistochemistry Kit (VS-0325-XY1578)
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- Species Reactivity: Human, Mouse, Rat
- Target: PCBP1
- Application: IHC
- Anti-Mouse PCBP1 Immunohistochemistry Kit (VS-0525-XY5230)
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- Species Reactivity: Human, Mouse, Rat
- Target: PCBP1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Molecular function
DNA-binding, Ribonucleoprotein, RNA-binding
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