Enzymes
Intracellular, Secreted (different isoforms)
Cell type enhanced (Oligodendrocytes, Hepatocytes, Horizontal cells, Theca cells)
Immune cell enhanced (NK-cell)
Cell line enhanced (BEWO, CACO-2, HEK93, Hep G2, OE19)
The PACE4A-I precursor protein seems to exist in the reticulum endoplasmic as both a monomer and a dimer-sized complex whereas mature PACE4A-I exists only as a monomer, suggesting that propeptide cleavage affects its tertiary or quaternary structure. Interacts (immature form including the propeptide) with RCN3; probably involved in the maturation and the secretion of PCSK6 (PubMed:16433634).
Hydrolase, Protease, Serine protease
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For Research Use Only. Not For Clinical Use.