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PDGFA
Anti-PDGFA Recombinant Antibody Products
- Recombinant Mouse Anti-PDGFA Antibody (CBL523) (NEUT-1842CQ)
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- Species Reactivity: Human
- Type: IgG1
- Application: Neut
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- Recombinant Mouse Anti-PDGFA Antibody (clone 4C1D6) (VS3-FY1111)
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- Type: Mouse IgG2a
- Application: ELISA, ICC, FC
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- Recombinant Mouse Anti-PDGFA Antibody (clone 4C1F4) (VS3-FY1112)
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- Type: Mouse IgG2a
- Application: ELISA, IHC, FC
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- AbPlus™ Anti-PDGFA Magnetic Beads (VS-0724-YC362) (VS-0724-YC362)
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- Target: PDGFA
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Human disease related genes, RAS pathway related proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Breast myoepithelial cells, Smooth muscle cells, Paneth cells, Alveolar cells type 1)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enriched (WM-115)
Interaction
Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.
Molecular function
Developmental protein, Growth factor, Mitogen
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