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PGA5
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Protein class
Enzymes, FDA approved drug targets
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Exocrine glandular cells)
Immune cell specificity
Group enriched (intermediate monocyte, non-classical monocyte, classical monocyte)
Cell line specificity
Cell line enriched (BJ hTERT+)
Molecular function
Aspartyl protease, Hydrolase, Protease
More Types Infomation
- Recombinant Mouse Anti-Human PGA5 Antibody (MOB-1887MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
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For Research Use Only. Not For Clinical Use.