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PHF21A
Anti-PHF21A Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Group enriched (Oligodendrocyte precursor cells, Oligodendrocytes, Astrocytes, Excitatory neurons, Inhibitory neurons, Microglial cells)
Immune cell specificity
Group enriched (basophil, neutrophil)
Cell line specificity
Low cell line specificity
Interaction
Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, it interacts directly with HDAC1, HDAC2, HMG20B/BRAF35, KDM1A and RCOR1/CoREST.
Molecular function
Chromatin regulator, DNA-binding, Repressor
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