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PIK3CG
Loading...Anti-PIK3CG Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Mouse Anti-PIK3CG Recombinant Antibody (clone 4B5D2) (VS3-XY1255)
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- Type: Mouse IgG1
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- Mouse Anti-PIK3CG Recombinant Antibody (clone 6H12) (VS3-XY1256)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
Compare
- Mouse Anti-NHP PIK3CG Recombinant Antibody (clone OTI6H5) (VS-1024-XY385)
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- Species Reactivity: Human, Mouse, Non-human primate
- Type: Mouse IgG2a
- Application: WB, IHC, IF
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- Anti-PIK3CG Immunohistochemistry Kit (VS-0525-XY5409)
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- Species Reactivity: Human
- Target: PIK3CG
- Application: IHC
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- Anti-Mouse PIK3CG Immunohistochemistry Kit (VS-0525-XY5410)
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- Species Reactivity: Human, Mouse, Rat
- Target: PIK3CG
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene.
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Plasma cells, Early spermatids, dendritic cells, NK-cells, B-cells, monocytes, granulocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, HL-60, HMC-1, Karpas-707, MOLT-4, U-266/70, U-937)
Interaction
Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with GRK2 through the PIK helical domain. Interaction with GRK2 is required for targeting to agonist-occupied receptor. Interacts with PDE3B (By similarity). Interacts with TPM2. Interacts with EPHA8; regulates integrin-mediated cell adhesion to substrate. Interacts with HRAS; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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