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PIK3R4
Loading...Anti-PIK3R4 Products
- Recombinant Mouse Anti-Human PIK3R4 Antibody (MOB-0991MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC, FC
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- Mouse Anti-PIK3R4 Recombinant Antibody (clone 5H3A11) (VS7-0425-WR613)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, ICC, FC
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- Mouse Anti-PIK3R4 Recombinant Antibody (clone 2C11E8) (VS7-0425-WR614)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ELISA
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- Anti-PIK3R4 Immunohistochemistry Kit (VS-0525-XY5416)
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- Species Reactivity: Human
- Target: PIK3R4
- Application: IHC
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- Anti-Mouse PIK3R4 Immunohistochemistry Kit (VS-0525-XY5417)
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- Species Reactivity: Human, Mouse, Rat
- Target: PIK3R4
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including early endosome to late endosome transport; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and phosphatidylinositol-3-phosphate biosynthetic process. Located in late endosome and microtubule cytoskeleton. Part of phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Mar 2025]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are PI3K complex I (PI3KC3-C1) containing ATG14, and PI3K complex II (PI3KC3-C2) containing UVRAG (PubMed:8999962, PubMed:19270696, PubMed:23878393, PubMed:25490155). PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex (PubMed:25490155). Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits, such as RUBCN, SH3GLB1/Bif-1, AMBRA1 and NRBF2 (PubMed:19270696, PubMed:20643123, PubMed:24785657). PI3KC3-C1 probably associates with PIK3CB (By similarity). Interacts with RAB7A in the presence of PIK3C3/VPS34 (PubMed:14617358). Interacts with NRBF2 (PubMed:24785657).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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