PITX3

Pituitary homeobox 3 is a protein in humans encoded by the PITX3 gene that can encode a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development, and the specification and terminal differentiation of mesencephalic dopamine neurons in the substantia nigra compacta that are lost in Parkinson's disease. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis (ASMD) and congenital cataracts. Associated diseases include Cataract 11, Multiple Types and Anterior Segment Dysgenesis 1. Its related pathways are Dopaminergic Neurogenesis.