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PLA2G5

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For Research Use Only. Not For Clinical Use.


Background

This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.
Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, RAS pathway related proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Sertoli cells, Leydig cells, Cardiomyocytes, Peritubular cells, Cone photoreceptor cells, Smooth muscle cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (U-2197)

Molecular function

Hydrolase

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