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PODXL2

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For Research Use Only. Not For Clinical Use.


Background

This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins.
Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Late spermatids, Bipolar cells, Horizontal cells, Spermatogonia, Early spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (RPMI-8226, SCLC-21H)

Interaction

Homodimer; disulfide-linked. Interacts with SELL, SELE and SELP.

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