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POLB
Loading...Anti-POLB Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IF, IP
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, IHC, IP, IF
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- AbPlus™ Anti-POLB Magnetic Beads (VS-0724-YC74) (VS-0724-YC74)
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- Target: POLB
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-POLB Immunohistochemistry Kit (VS-0525-XY5544)
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- Species Reactivity: Human
- Target: POLB
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage.
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HMC-1)
Interaction
Monomer. Interacts with APEX1, HUWE1/ARF-BP1, STUB1/CHIP and USP47. Interacts with FAM168A (PubMed:25260657).
Molecular function
DNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase
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