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POU4F1
Loading...Anti-POU4F1 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, IP, IF, IHC, ELISA
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC
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- Rabbit Anti-POU4F1 Recombinant Antibody (clone AFY0033) (MOR-0062-FY)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: ICC, IHC-P, IP, WB
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Skeletal myocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HEK93, HEL, JURKAT, REH, RH-30, SCLC-21H, U-266/70)
Interaction
Interacts (via N-terminus) with RIT2; the interaction controls POU4F1 transactivation activity on some neuronal target genes. Isoform 1 interacts with POU4F2; this interaction inhibits both POU4F1 DNA-binding and transcriptional activities. Isoform 1 interacts (C-terminus) with ESR1 (via DNA-binding domain); this interaction decreases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner.
Molecular function
Developmental protein, DNA-binding
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