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PPARGC1B
Loading...Anti-PPARGC1B Products
- Recombinant Anti-Human PGC-1 beta Antibody (MOB-0311MC)
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- Species Reactivity: Human
- Application: ELISA, FACS, WB
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity.
Protein class
Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cone photoreceptor cells, Bipolar cells, Rod photoreceptor cells)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Low cell line specificity
Interaction
Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen receptor alpha/ESR1.
Molecular function
Activator, RNA-binding
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Related Signaling Pathways
PPAR Signaling Pathway