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Anti-PPP3R1 Recombinant Antibody Products
Loading...Anti-PPP3R1 Products
- Anti-PPP3R1 Immunohistochemistry Kit (VS-0325-XY1727)
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- Species Reactivity: Human, Mouse, Rat
- Target: PPP3R1
- Application: IHC
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- Anti-Human PPP3R1 Immunohistochemistry Kit (VS-0525-XY5639)
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- Species Reactivity: Human, Frog
- Target: PPP3R1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Creative Biolabs, your trusted source for immunology and signal transduction research tools, offers highly specific anti-PPP3R1 recombinant antibodies (rAbs). As the key regulatory B subunit of calcineurin phosphatase, PPP3R1 sits at the center of a pathway targeted by some of the most well-known immunosuppressant drugs. Creative's recombinant antibodies are a critical reagent to study T-cell activation, organ transplantation, and the mechanism of action of calcineurin inhibitors.
PPP3R1: The Regulatory Subunit of Calcineurin
Protein Phosphatase 3 Regulatory Subunit B, Alpha (PPP3R1), also known as Calcineurin B (CnB), is the 19 kDa regulatory subunit of calcium/calmodulin-dependent protein phosphatase calcineurin. PPP3R1 has 4 EF-hand motifs for binding calcium ions. Binding calcium causes a conformational change that activates the catalytic A subunit. Activated calcineurin dephosphorylates the NFAT family of transcription factors, which allows them to enter the nucleus and activate expression of IL-2 and other genes necessary for T-cell activation. The action of calcineurin is inhibited by the immunosuppressant drugs cyclosporine and tacrolimus.
Alternative Names
CNB; CNB1; CALNB1
Background
Protein class
Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Low cell line specificity
Interaction
Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (PubMed: 8524402, 12218175, 12357034, 17498738, 22343722, 23468591, 26794871, 27974827). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). Interacts with catalytic subunit PPP3CA/calcineurin A (PubMed:8524402, 12218175, 12357034, 17498738, 22343722, 23468591, 27974827). Interacts with catalytic subunit PPP3CB/calcineurin A (PubMed:26794871). Interacts with CIB1 (via C-terminal region); the interaction increases upon cardiomyocyte hypertrophy (By similarity). Interacts with RCAN1 (PubMed:12809556). Interacts with SPATA33 (via PQIIIT motif) (PubMed:34446558).
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Anti-PPP3R1 rAb Products
Creative Biolabs' anti-PPP3R1 recombinant antibodies have been engineered for the highest level of specificity and performance. They are thoroughly validated and provide highly specific detection of the CnB subunit in a variety of tissues. Our antibodies have been optimized for applications like Western Blot to measure expression and co-immunoprecipitation to study the composition of the calcineurin complex.
Table 1. Featured anti-PPP3R1 recombinant antibody products at Creative Biolabs.
| Cat. No. | Product Name | Target Species | Host Species | Applications |
| MOB-1949MZ | Recombinant Mouse Anti-Human PPP3R1 Antibody (clone CF3.2) | Human | Mouse IgG | WB, ELISA |
Customer Reviews
Excellent
A**raRecombinant Mouse Anti-Human PPP3R1 Antibody (clone CF3.2)
I've been using antibodies from Creative Biolabs for quite some time, and their quality is always good. Their anti-Calcineurin B antibody is no exception. The quality is excellent and it works perfectly, which is important for our work on the action of immunosuppressant drugs.
11/Oct/2024
rAb Production
Creative Biolabs is dedicated to supporting the specialized field of immunology and the study of signal transduction with the most advanced antibody production platforms. Our anti-PPP3R1 recombinant antibodies are expressed in optimized systems to ensure that they specifically recognize the native protein in the context of the enzyme complex, providing a highly specific and active research tool.
Featured Anti-PPP3R1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-PPP3R1 recombinant antibody production.
Fig.2 Gram-scale anti-PPP3R1 recombinant antibody production.
rAb Modalities
Creative Biolabs is dedicated to supporting scientific discovery with a wide variety of flexible antibody modalities. Our anti-PPP3R1 recombinant antibodies are available in customizable formats to address many different research needs, enabling scientists across the world to study this critical phosphatase.
Fig.3 Full-length anti-PPP3R1 recombinant antibody production and modalities.
Peer into the details of T-cell activation with the power of Creative Biolabs' anti-PPP3R1 recombinant antibodies. Creative's library of rigorously validated and highly consistent research tools will provide a solid foundation for your work on this key therapeutic target. Reach out to our scientific team today.
