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PRIMPOL
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a DNA primase-polymerase that belongs to a superfamily of archaeao-eukaryotic primases. Members of this family have primase activity, catalyzing the synthesis of short RNA primers that serve as starting points for DNA synthesis, as well as DNA polymerase activity.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Intestinal goblet cells)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Low cell line specificity
Interaction
Interacts with RPA1; leading to recruitment to chromatin and stimulate DNA primase activity (PubMed:24126761, 25550423, 28396594, 28534480). Interacts with SSBP1 (PubMed:25550423). Interacts with POLDIP2; leading to enhance DNA polymerase activity (PubMed:26984527).
Molecular function
DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
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