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PRIMPOL

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Anti-PRIMPOL Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes a DNA primase-polymerase that belongs to a superfamily of archaeao-eukaryotic primases. Members of this family have primase activity, catalyzing the synthesis of short RNA primers that serve as starting points for DNA synthesis, as well as DNA polymerase activity.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Intestinal goblet cells)

Immune cell specificity

Immune cell enhanced (eosinophil)

Cell line specificity

Low cell line specificity

Interaction

Interacts with RPA1; leading to recruitment to chromatin and stimulate DNA primase activity (PubMed:24126761, 25550423, 28396594, 28534480). Interacts with SSBP1 (PubMed:25550423). Interacts with POLDIP2; leading to enhance DNA polymerase activity (PubMed:26984527).

Molecular function

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

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