Anti-PRKACA Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a leader in cell signaling research, and our anti-PRKACA recombinant antibodies are among the best in the field. PRKACA, the alpha catalytic subunit of the widely expressed and essential cAMP-dependent protein kinase (PKA), is a master regulator of hundreds of cellular processes. Our high-quality antibodies provide essential tools to study signal transduction in every physiological system and how it goes awry in cancer and endocrine disorders.

PRKACA: The Catalytic Engine of PKA Signaling

Protein Kinase CAMP-Activated Catalytic Subunit Alpha (PRKACA) is the most ubiquitously expressed catalytic subunit of Protein Kinase A. PKA is found as an inactive tetramer composed of two regulatory subunits and two catalytic subunits. In response to an increase in intracellular cAMP levels, cAMP binds to the regulatory subunits and this causes a conformational change that dissociates and activates the catalytic subunits such as PRKACA. The activated kinase phosphorylates hundreds of substrate proteins on serine and threonine residues to control diverse processes including metabolism, gene transcription, cell growth, and division. Activating mutations in PRKACA have been implicated as drivers of certain endocrine tumors.

Alternative Names

PKACA; PPNAD4

Background

It phosphorylates various other proteins and substrates, thereby modifying their activity. Protein kinase A catalytic subunit (PKA Cα) belongs to the AGC kinase family (protein kinases A, G, and C) and plays a role in the regulation of cellular processes including glucose metabolism, cell cycle progression, and contextual memory.

Anti-PRKACA rAb Products

Our anti-PRKACA recombinant antibodies are designed for exceptional specificity and performance. They are extensively validated to detect the alpha catalytic subunit in a wide range of cell and tissue lysates. Optimized for challenging applications such as Western Blot and IHC and for use in kinase assays, these rAbs provide the specificity needed to probe the heart of cAMP signaling.

Table 1. Featured anti-PRKACA recombinant antibody products at Creative Biolabs.

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rAb Production

To help accelerate the discovery of novel therapies, Creative Biolabs uses advanced production platforms. Our anti-PRKACA recombinant antibodies are expressed in systems that have been optimized to produce antibodies that accurately recognize the native kinase, so you can be confident in a product that has high biological activity.

Featured Anti-PRKACA Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-PRKACA recombinant antibody production.

Fig.2 Gram-scale anti-PRKACA recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing innovative products and solutions for the field of cell biology. Our anti-PRKACA recombinant antibodies are available in multiple customizable formats to help researchers from around the world study this important signaling kinase.

Fig.3 Full-length anti-PRKACA recombinant antibody production and modalities.

Target this important signaling kinase with Creative Biolabs' high-quality anti-PRKACA recombinant antibodies. Our portfolio offers the specificity and functional activity you need to study the central role of PKA in health and disease. Trust our expertise and use our products to provide a solid foundation for your research. Contact our scientific team today.