Anti-PRKAR2A Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Cell signaling experts at Creative Biolabs provide the best quality anti-PRKAR2A recombinant antibodies to help you map out the architecture of cell signaling. As the Type 2 alpha regulatory subunit of PKA, PRKAR2A serves as a critical docking site that anchors the kinase to a defined subcellular location. Creative Biolabs' elite, isoform-specific anti-PRKAR2A antibodies are an essential research tool for elucidating the spatial organization of cAMP signaling and its effect on cell physiology.

PRKAR2A: An Anchoring Hub for PKA Signaling

Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha (PRKAR2A) is one of four major regulatory subunits of the PKA holoenzyme. Like the other regulatory subunits, it functions to bind and inactivate the PKA catalytic subunit in a cAMP-dependent manner. The Type 2 subunits (R2A and R2B) differ from the Type 1 subunits in that they are themselves substrates for autophosphorylation by the catalytic subunit. More importantly for its role in determining PKA subcellular organization, the Type 2 regulatory subunits bind to A-Kinase Anchoring Proteins (AKAPs) and mediate PKA complex localization to defined subcellular compartments. By tethering PKA to its AKAPs, these anchoring proteins ensure that PKA is optimally positioned near its cognate substrates for maximal spatial and temporal control over cAMP signaling.

Alternative Names

PKR2; PRKAR2

Background

cAMP is a second messenger important in many biological processes. cAMP mediates its actions through activation of cAMP-dependent protein kinase, which in turn transduces the signal by phosphorylating various target proteins. The inactive kinase holoenzyme is a tetramer of two regulatory and two catalytic subunits. cAMP causes dissociation of the inactive holoenzyme into a dimer of regulatory subunits each bound to 4 cAMP molecules and two free monomeric catalytic subunits. In humans, four distinct regulatory subunits and three catalytic subunits have been identified. The protein encoded by this gene is one of the regulatory subunits. This regulatory subunit can be phosphorylated by the activated catalytic subunit. It may bind to a variety of A-kinase anchoring proteins and may determine the subcellular localization of the cAMP-dependent protein kinase.

Anti-PRKAR2A rAb Products

Our anti-PRKAR2A recombinant antibodies are developed to the highest standards of specificity and validated to detect only the R2-alpha isoform without cross-reactivity to the other PKA regulatory subunits. This level of specificity is critical in the study of the cell's distinct PKA complexes. In addition, our rAbs have been optimized for standard applications such as immunofluorescence and co-immunoprecipitation studies of PKA-AKAP interactions to provide clear, consistent results.

Table 1. Featured anti-PRKAR2A recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

To meet the needs of today's advanced cell biology research, Creative Biolabs utilizes state-of-the-art production technologies. Our anti-PRKAR2A recombinant antibodies are expressed in systems that have been optimized to ensure they recognize the unique epitopes of this anchoring protein for a highly specific research tool.

Featured Anti-PRKAR2A Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-PRKAR2A recombinant antibody production.

Fig.2 Gram-scale anti-PRKAR2A recombinant antibody production.

rAb Modalities

Creative Biolabs prides itself on being a forward-thinking supplier that offers a range of flexible solutions to meet your research needs. Our anti-PRKAR2A recombinant antibodies are available in a variety of customizable modalities to support a range of experimental designs, giving researchers around the world the power to study the architecture of cell signaling.

Fig.3 Full-length anti-PRKAR2A recombinant antibody production and modalities.

Decode the organization of cell signaling with Creative Biolabs' superior anti-PRKAR2A recombinant antibodies. Our entire portfolio is defined by our uncompromising validation process and outstanding performance, making our products the ideal tools for your research. Don't take chances with subpar antibodies – trust our expertise and accelerate your next scientific breakthrough. Contact our specialists today.