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PRKAR2A
Anti-PRKAR2A Recombinant Antibody Products
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- Species Reactivity: Human, Mouse, Rat, Porcine
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC/IF, IHC-P, IP, WB
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- Anti-PRKAR2A Immunohistochemistry Kit (VS-0325-XY1748)
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- Species Reactivity: Human, Mouse, Rat
- Target: PRKAR2A
- Application: IHC
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For Research Use Only. Not For Clinical Use.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase.
Protein class
Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3. Interacts with the phosphorylated form of PJA2. Interacts with MYRIP. This interaction may link PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). Forms a complex composed of PRKAR2A, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (PubMed:27484798). Interacts with ADCY8; inhibits adenylate cyclase activity through PKA phosphorylation (PubMed:22976297).
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