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PRKCE
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Late spermatids, Excitatory neurons, Early spermatids, Oligodendrocyte precursor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (REH, TIME)
Interaction
Forms a ternary complex with TRIM63 and RACK1/GN2BL1 (By similarity). Can form a complex with PDLIM5 and N-type calcium channel (By similarity). Interacts with COPB1 (By similarity). Interacts with DGKQ (PubMed:15632189). Interacts with STAT3 (PubMed:17875724). Interacts with YWHAB (By similarity). Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner (PubMed:20353823). Interacts (via phorbol-ester/DAG-type 2 domain) with PRPH and VIM (PubMed:18408015). Interacts with NLRP5/MATER (PubMed:19542546). Interacts with PRKCH upstream open reading frame 2; the interaction leads to inhibition of kinase activity (PubMed:34593629).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Phage display library screening
- Type: IgG
- Application: WB, IP, ELISA, IHC-FoFr
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-Fr
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: ELISA, WB, IP, ICC
-
- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, IHC, FC, FuncS
-
- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC
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For Research Use Only. Not For Clinical Use.