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PROC
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Cell line enriched (Hep G2)
Interaction
Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.
Molecular function
Hydrolase, Protease, Serine protease
More Types Infomation
- Recombinant Anti-sheep PROC Antibody scFv Fragment (MOB-804-S(P))
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- Derivation: Mouse
- Species Reactivity: sheep
- Type: scFv
- Application: ELISA, IF, FuncS
- Recombinant Anti-sheep PROC Antibody Fab Fragment (MOB-804-F(E))
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- Derivation: Mouse
- Species Reactivity: sheep
- Type: Fab
- Application: FC, ELISA, FuncS
- Recombinant Anti-sheep PROC Antibody (MOB-804)
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- Derivation: Mouse
- Species Reactivity: sheep
- Type: IgG
- Application: WB, IF, FuncS
- Recombinant Rat Anti-Proc Antibody (9071) (NEUT-1886CQ)
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- Species Reactivity: Mouse
- Application: ELISA, Inhib, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: RIA, WB, ELISA
- Mouse Anti-PROC Recombinant Antibody (clone HPC-4) (FAMAB-1298CQ)
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- Species Reactivity: Baboon, Human
- Type: Mouse IgG1
- Application: Block, ELISA
- Rabbit Anti-PROC Polyclonal Antibody (MRO-2276-CN) (MRO-2276-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Mouse Anti-PROC Antibody (clone HPC-4), mRNA (FAMAB-1298CQ-mRNA)
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- Species Reactivity: Baboon, Human
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
- Recombinant Human Anti-sheep PROC Antibody scFv Fragment (MHH-804-S(P))
-
- Derivation: Human
- Species Reactivity: sheep
- Type: scFv
- Application: WB, Neut, FuncS
-
- Derivation: Human
- Species Reactivity: sheep
- Type: IgG
- Application: FC, IP, FuncS
- Anti-Human PROC Therapeutical Antibody (TAB-713CL)
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- Derivation: Rabbit
- Species Reactivity: Human
- Type: Antibody
- Rabbit Anti-PROC Antibody, mRNA (TAB-713CL-mRNA)
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- Species Reactivity: Human
- Mouse Anti-PROC Recombinant Antibody; scFv Fragment (HPAB-0240-YC-S(P)) (HPAB-0240-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-PROC Recombinant Antibody; Fab Fragment (HPAB-0240-YC-F(E)) (HPAB-0240-YC-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Drotrecogin alfa (TP-052CL)
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- CAS number: 60202-16-6
- Mouse Anti-PROC Recombinant Antibody (HPAB-0240-YC) (HPAB-0240-YC)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
-
- Derivation: Rabbit
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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For Research Use Only. Not For Clinical Use.