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PRTFDC1
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For Research Use Only. Not For Clinical Use.
Background
Phosphoribosyltransferase domain containing protein 1 (PRTFDC1) is present in the human genome. A recent study identified this homologue as a gene potentially involved in the development of ovarian cancer. In a genome-wide screening for differently methylated promoter islands, PRTFDC1 is transcribed in ovarian cancer cell lines with unmethylated DNA but not in cancer cell lines with methylated DNA. A similar study demonstrated that restoring PRTFDC1 in oral squamous cell carcinomas cells lacking its expression inhibited cell growth.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells)
Immune cell specificity
Immune cell enriched (NK-cell)
Cell line specificity
Cell line enhanced (CACO-2, CAPAN-2, HEL)
Interaction
Homodimer.
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