PSMB9

Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins

Intracellular

Cell type enhanced (NK-cells, monocytes, Proximal enterocytes)

Low immune cell specificity

Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, Daudi)

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB6. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. (Microbial infection) Interacts with HIV-1 TAT protein.

Hydrolase, Protease, Threonine protease