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PTGER3
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For Research Use Only. Not For Clinical Use.
Background
Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation.
Protein class
FDA approved drug targets, G-protein coupled receptors
Predicted location
Membrane
Single cell type specificity
Group enriched (Distal tubular cells, Langerhans cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (ASC diff, HAP1, HDLM-2, HEL, T-47d)
Interaction
Interacts (via C-terminus) with MKLN1.
Molecular function
G-protein coupled receptor, Receptor, Transducer
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