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PUM2

Anti-PUM2 Products

Recombinant Mouse anti-Human PUM2 Monoclonal antibody (EML1338) (MOB-0803CT)
- Species Reactivity: Human
- Application: WB
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Hi-Affi™ Recombinant Rabbit Anti-PUM2 Monoclonal Antibody (DS2942AB) (MOR-2942)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, ICC
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CytoStream™ Rabbit Anti-PUM2 Recombinant Antibody (VS13-YC962) (VS13-YC962)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP, FC
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For Research Use Only. Not For Clinical Use.

Background

This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells.

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Homodimer; homodimerizes in vitro. Interacts with DAZ1, DAZL and NANOS1 via its pumilio repeats. Interacts with NANOS3 (By similarity). Interacts with SNAPIN. Recruits the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Interacts with DDX20. In case of viral infection, interacts with DHX58 (PubMed:25340845). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).

Molecular function

RNA-binding

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