PolyQ

A series of diseases caused by polyglutamine are called polyglutamine diseases because of the repeated sequence coding of the first two of the three bases of CAG in the coding region, which is the translation of the two from the three in the gene description. The abnormal CAG repeat sequence of PolyQ disease has a trend of continuous expansion, which leads to an earlier age of offspring onset and a faster progression of disease, called genetic preemergence.The pathogenesis of polyglutamine disease is a hot topic at home and abroad now. The pathogenesis of polyglutamine disease is caused by the nucleation of mutated proteins. The excessive duplication of the three letters of the DNA of spermatogenic stem cells is related, although the pathogenic proteins are widely expressed in the central nervous system, and each disease has a specific group of susceptible neurons, resulting in different forms of neurodegeneration and disease phenotypes.